Successful identification of blood vessel blockage is a crucial step for Alzheimer's disease diagnosis. These blocks can be identified from the spatial and time-depth variable Two-Photon Excitation Microscopy (TPEF) images of the brain blood vessels using machine learning methods. In this study, we propose several preprocessing schemes to improve the performance of these methods. Our method includes 3D-point cloud data extraction from image modality and their feature-space fusion to leverage complementary information inherent in different modalities. We also enforce the learned representation to be sequence-order invariant by utilizing bi-direction dataflow. Experimental results on The Clog Loss dataset show that our proposed method consistently outperforms the state-of-the-art preprocessing methods in stalled and non-stalled vessel classification.

Non-negative matrix factorization is a popular unsupervised machine learning algorithm for extracting meaningful features from data which are inherently non-negative. However, such data sets may often contain privacy-sensitive user data, and therefore, we may need to take necessary steps to ensure the privacy of the users while analyzing the data. In this work, we focus on developing a Non-negative matrix factorization algorithm in the privacy-preserving framework. More specifically, we propose a novel privacy-preserving algorithm for non-negative matrix factorisation capable of operating on private data, while achieving results comparable to those of the non-private algorithm. We design the framework such that one has the control to select the degree of privacy grantee based on the utility gap. We show our proposed framework's performance in six real data sets. The experimental results show that our proposed method can achieve very close performance with the non-private algorithm under some parameter regime, while ensuring strict privacy.

机器学习的进步为低端互联网节点（例如微控制器）带来了新的机会，将情报带入了情报。传统的机器学习部署具有较高的记忆力，并计算足迹阻碍了其在超资源约束的微控制器上的直接部署。本文强调了为MicroController类设备启用机载机器学习的独特要求。研究人员为资源有限的应用程序使用专门的模型开发工作流程，以确保计算和延迟预算在设备限制之内，同时仍保持所需的性能。我们表征了微控制器类设备的机器学习模型开发的广泛适用的闭环工作流程，并表明几类应用程序采用了它的特定实例。我们通过展示多种用例，将定性和数值见解介绍到模型开发的不同阶段。最后，我们确定了开放的研究挑战和未解决的问题，要求仔细考虑前进。

Transformer-based language models have been shown to be highly effective for several NLP tasks. In this paper, we consider three transformer models, BERT, RoBERTa, and XLNet, in both small and large version, and investigate how faithful their representations are with respect to the semantic content of texts. We formalize a notion of semantic faithfulness, in which the semantic content of a text should causally figure in a model's inferences in question answering. We then test this notion by observing a model's behavior on answering questions about a story after performing two novel semantic interventions -- deletion intervention and negation intervention. While transformer models achieve high performance on standard question answering tasks, we show that they fail to be semantically faithful once we perform these interventions for a significant number of cases (~50% for deletion intervention, and ~20% drop in accuracy for negation intervention). We then propose an intervention-based training regime that can mitigate the undesirable effects for deletion intervention by a significant margin (from ~50% to ~6%). We analyze the inner-workings of the models to better understand the effectiveness of intervention-based training for deletion intervention. But we show that this training does not attenuate other aspects of semantic unfaithfulness such as the models' inability to deal with negation intervention or to capture the predicate-argument structure of texts. We also test InstructGPT, via prompting, for its ability to handle the two interventions and to capture predicate-argument structure. While InstructGPT models do achieve very high performance on predicate-argument structure task, they fail to respond adequately to our deletion and negation interventions.

Prompting large language models has enabled significant recent progress in multi-step reasoning over text. However, when applied to text generation from semi-structured data (e.g., graphs or tables), these methods typically suffer from low semantic coverage, hallucination, and logical inconsistency. We propose MURMUR, a neuro-symbolic modular approach to text generation from semi-structured data with multi-step reasoning. MURMUR is a best-first search method that generates reasoning paths using: (1) neural and symbolic modules with specific linguistic and logical skills, (2) a grammar whose production rules define valid compositions of modules, and (3) value functions that assess the quality of each reasoning step. We conduct experiments on two diverse data-to-text generation tasks like WebNLG and LogicNLG. These tasks differ in their data representations (graphs and tables) and span multiple linguistic and logical skills. MURMUR obtains significant improvements over recent few-shot baselines like direct prompting and chain-of-thought prompting, while also achieving comparable performance to fine-tuned GPT-2 on out-of-domain data. Moreover, human evaluation shows that MURMUR generates highly faithful and correct reasoning paths that lead to 26% more logically consistent summaries on LogicNLG, compared to direct prompting.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Flooding is one of the most disastrous natural hazards, responsible for substantial economic losses. A predictive model for flood-induced financial damages is useful for many applications such as climate change adaptation planning and insurance underwriting. This research assesses the predictive capability of regressors constructed on the National Flood Insurance Program (NFIP) dataset using neural networks (Conditional Generative Adversarial Networks), decision trees (Extreme Gradient Boosting), and kernel-based regressors (Gaussian Process). The assessment highlights the most informative predictors for regression. The distribution for claims amount inference is modeled with a Burr distribution permitting the introduction of a bias correction scheme and increasing the regressor's predictive capability. Aiming to study the interaction with physical variables, we incorporate Daymet rainfall estimation to NFIP as an additional predictor. A study on the coastal counties in the eight US South-West states resulted in an $R^2=0.807$. Further analysis of 11 counties with a significant number of claims in the NFIP dataset reveals that Extreme Gradient Boosting provides the best results, that bias correction significantly improves the similarity with the reference distribution, and that the rainfall predictor strengthens the regressor performance.

Deep Learning and Machine Learning based models have become extremely popular in text processing and information retrieval. However, the non-linear structures present inside the networks make these models largely inscrutable. A significant body of research has focused on increasing the transparency of these models. This article provides a broad overview of research on the explainability and interpretability of natural language processing and information retrieval methods. More specifically, we survey approaches that have been applied to explain word embeddings, sequence modeling, attention modules, transformers, BERT, and document ranking. The concluding section suggests some possible directions for future research on this topic.

The internet has had a dramatic effect on the healthcare industry, allowing documents to be saved, shared, and managed digitally. This has made it easier to locate and share important data, improving patient care and providing more opportunities for medical studies. As there is so much data accessible to doctors and patients alike, summarizing it has become increasingly necessary - this has been supported through the introduction of deep learning and transformer-based networks, which have boosted the sector significantly in recent years. This paper gives a comprehensive survey of the current techniques and trends in medical summarization

Modeling the risk of extreme weather events in a changing climate is essential for developing effective adaptation and mitigation strategies. Although the available low-resolution climate models capture different scenarios, accurate risk assessment for mitigation and adaption often demands detail that they typically cannot resolve. Here, we develop a dynamic data-driven downscaling (super-resolution) method that incorporates physics and statistics in a generative framework to learn the fine-scale spatial details of rainfall. Our method transforms coarse-resolution ($0.25^{\circ} \times 0.25^{\circ}$) climate model outputs into high-resolution ($0.01^{\circ} \times 0.01^{\circ}$) rainfall fields while efficaciously quantifying uncertainty. Results indicate that the downscaled rainfall fields closely match observed spatial fields and their risk distributions.